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Impact of a nurse‐led home and clinic‐based secondary prevention programme to prevent progressive cardiac dysfunction in high‐risk individuals: the Nurse‐led Intervention for Less Chronic Heart Failure (NIL‐CHF) randomized controlled study 下载免费PDF全文
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Melinda G Arnett Lisa M Muglia Gloria Laryea Louis J Muglia 《Neuropsychopharmacology》2016,41(1):245-260
The normal function of the hypothalamic-pituitary-adrenal (HPA) axis, and resultant glucocorticoid (GC) secretion, is essential for human health. Disruption of GC regulation is associated with pathologic, psychological, and physiological disease states such as depression, post-traumatic stress disorder, hypertension, diabetes, and osteopenia, among others. As such, understanding the mechanisms by which HPA output is tightly regulated in its responses to environmental stressors and circadian cues has been an active area of investigation for decades. Over the last 20 years, however, advances in gene targeting and genome modification in rodent models have allowed the detailed dissection of roles for key molecular mediators and brain regions responsible for this control in vivo to emerge. Here, we summarize work done to elucidate the function of critical neuropeptide systems, GC-signaling targets, and inflammation-associated pathways in HPA axis regulation and behavior, and highlight areas for future investigation. 相似文献
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Multiple opioids are known to trigger mast cell degranulation. We report the case of a neonate with blistering skin lesions at birth who died of multi‐organ failure after administration of morphine. Given the excessive histamine release and potential complications associated with morphine administration, alternative opioids and adjuvants should be considered in infants presenting with evidence of bullous or infiltrative skin lesions until mastocytosis is ruled out. 相似文献
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Vipin Kumar Menon Santosh George Aruna A. Shanti Anuradha Saravanabavan Prasanna Samuel Sasirekha Ramani Mary K. Estes Gagandeep Kang 《Journal of clinical microbiology》2013,51(7):2391-2395
Human and bovine norovirus virus-like particles were used to evaluate antibodies in Indian children at ages 6 and 36 months and their mothers. Antibodies to genogroup II viruses were acquired early and were more prevalent than antibodies to genogroup I. Low levels of IgG antibodies against bovine noroviruses indicate possible zoonotic transmission. 相似文献
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